Controlling cell morphology on amino acid-modified cellulose

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  2. Dr Deepak Kalaskar
Author(s)Kalaskar DM, Gough JE, Ulijn RV, Sampson WW, Scurr DJ, Rutten FJ, Alexander MR, Merry CLR, Eichhorn SJ
Publication type Article
JournalSoft Matter
Year2008
Volume4
Issue5
Pages1059-1065
ISSN (print)1744-683X
ISSN (electronic)1744-6848
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This study shows that it is possible to affect the morphology and spreading of fibroblast cells on amino acid-modified cellulose-based fibrous networks. Hydrophilic (Gly, Ser), aliphatic (Ala, Val, Leu, Ile) and aromatic amino acids (Phe, Tyr, Trp), coupled to the cellulose via esterification, give rise to different cell morphologies. Modified cellulosic substrates are analysed using time of flight secondary ion mass spectrometry (TOF-SIMS), demonstrating that amino acids are coupled and uniformly distributed over the surface of the samples. Remarkably, it is shown that it is the aromatic amino acids, and in particular Trp, that give rise to significantly enhanced cell spreading. This enhanced effect is shown to be linked to an increase in the adsorption of fibronectin in the presence of aromatic bound amino acids.
PublisherRoyal Society of Chemistry
URLhttp://dx.doi.org/10.1039/b719706n
DOI10.1039/b719706n
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