Intensified Azeotropic Distillation: A Strategy for Optimizing Direct Amidation

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  2. Dr Christophe Grosjean
  3. Julie Parker
  4. Professor Allen Wright
Author(s)Grosjean C, Parker J, Thirsk K, Wright AR
Publication type Article
JournalOrganic Process Research and Development
Year2012
Volume16
Issue5
Pages781-787
ISSN (print)1083-6160
ISSN (electronic)1520-586X
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The direct synthesis of amides from the corresponding carboxylic acids and amines is shown to operate under varying degrees of mixed kinetic and mass transfer rate control when water is removed by azeotropic distillation. Unless the volumetric heat input rate is reported, it is not possible to make a valid comparison between different catalysts, as the difference in Qboil alone can be responsible for the apparent difference in observed rate. A systematic approach is developed to quantify the contribution of boil-up rate to conversion rate and so decouple the physical rates from the chemistry. Intensive boiling is used to improve the removal of water during azeotropic distillation and considerably enhance conversion. The results show that some acylations previously thought to be difficult or impossible can be achieved in the absence of coupling agents under green conditions. The use of a cascade of CSTR flow reactors operating under intensified conditions is assessed for scale up of direct amidation reactions and compared to a production scale batch reactor. The findings and conclusions of this work have general applicability to all condensation reactions.
PublisherAmerican Chemical Society
URLhttp://dx.doi.org/10.1021/op300058f
DOI10.1021/op300058f
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