About Open Access
The Neuropathology of Vascular Disease in the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS)
Lookup NU author(s)
Dr Blossom Stephan
Professor Carol Brayne
Richardson K, Stephan BC, Ince PG, Brayne C, Matthews FE, Esiri MM
Current Alzheimer Research
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Background Vascular disease is associated with increased risk of dementia. Vascular health worsens with age. We investigated the relationship between self-reported vascular disease and brain pathology. Methods Brain donations to the population-based MRC Cognitive Function and Ageing Study (n=456, age range 66-103 years) were assessed using a standard protocol for Alzheimer's Disease (AD) and cerebrovascular pathology. History of stroke, angina, diabetes, medicated hypertension and heart attack were identified from self- and proxy-report interviews, retrospective informant interviews and death certificates. Logistic regression was used to estimate associations between each health condition and dichotomised neuropathological variables adjusted for age and sex. Results Stroke (36%), angina (23%), diabetes (12%), medicated hypertension (35%) and heart attack (22%) were frequently reported. Self-reported stroke was strongly associated with vascular, but not AD pathology. Medicated hypertension was associated with increased microinfarcts (OR=2.1, 95%CI=1.3-3.7) and less severe neocortical tangles (OR=0.5, 95%CI=0.3-0.8) and cerebral amyloid angiopathy (OR=0.5, 95%CI=0.3-0.8). Heart attack was associated with increased microinfarcts (OR=2.1, 95%CI=1.2-3.9). Conclusions Vascular risk factors were not associated with an increased burden of AD pathology at death in old age. A positive association between indices of systemic cardiovascular health (treated hypertension and ischaemic heart disease) and cerebral microinfarcts emerged. The findings support the view that cerebral small vessel disease and cardiovascular disease are inter-related. Microinfarcts are emerging as an important correlate of age-related vascular cognitive impairment and the findings add weight to the argument for strategies to improve general cardiovascular health as a potential preventative strategy against cognitive decline in later life.
Bentham Science Publishers Ltd.
Newcastle University Library, NE2 4HQ, United Kingdom. Tel: 0044 (191) 222 7657
©2011 Newcastle University Library