Downstream intronic splicing enhancers

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  2. Dr Julian Venables
Author(s)Venables JP
Publication type Article
JournalFEBS Letters
Year2007
Volume581
Issue22
Pages4127-4131
ISSN (print)0014-5793
ISSN (electronic)1873-3468
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Alternative splicing leads to multiple proteins from individual genes and the most common deviation from the norm is precise exon omission. Mutations that cause this can be found deep in introns, especially downstream of the cassette exon. This review summarises what is known about these intronic splicing enhancers and their RNA-binding proteins that cause spliceosome assembly on the upstream exon.
PublisherElsevier BV
URLhttp://dx.doi.org/10.1016/j.febslet.2007.08.012
DOI10.1016/j.febslet.2007.08.012
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