Age-related changes in the contractile and passive arterial properties of murine mesenteric small arteries are altered by caveolin-1 knockout
- Lookup NU author(s)
- Julie Taggart
- Professor Michael Taggart
|
|
|
|
| Author(s) | | Hausman N, Martin J, Taggart MJ, Austin C |
| Publication type | | Article |
| Journal | | Journal of Cellular and Molecular Medicine |
| Year | | 2012 |
| Volume | | 16 |
| Issue | | 8 |
| Pages | | 1720-1730 |
| ISSN (print) | | 1582-1838 |
| ISSN (electronic) | | 1582-4934 |
|
|
|
| Full text for this publication is not currently held within this repository. Alternative links are provided below where available. |
|
|
|
|
| Caveolin-1, an integral protein of caveolae, is associated with multiple cardiovascular signalling pathways. Caveolin-1 knockout (KO) mice have a reduced lifespan. As changes in artery structure and function are associated with ageing we have investigated the role of caveolin-1 ablation on age-related changes of small artery contractility and passive mechanical propertes. Mesenteric small arteries isolated from 3 and 12 month wild type (WT) and caveolin-1 KO mice were mounted on a pressure myograph and changes in passive and functional arterial properties were continuously monitored. In WT mice ageing was associated with a reduction in arterial contractility to noradrenaline which was reversed by inhibition of nitric oxide synthase (NOS) with L-NNA. Similarly, in 3 month old mice, caveolin-1 KO reduced contractility to noradrenaline by an L-NNA-sensitive mechanism. However, ageing in caveolin-1 KO mice was not associated with any further change in contractility. In WT mice ageing was associated with an increased passive arterial diameter and cross-sectional area (CSA), consistent with outward remodelling of the arterial wall, and a reduced arterial distensibility. Caveolin-1 ablation at 3 months of age resulted in similar changes in passive arterial properties to those observed with ageing in WT animals. However, ageing in caveolin-1 KO mice resulted in a reduced arterial CSA indicating different effects on passive structural characteristics from that observed in WT mice. Thus, caveolin-1 mice show abnormalities of small mesenteric artery function and passive mechanical characteristics indicative of premature vascular ageing. Moreover, caveolin-1 ablation modulates the age-related changes usually observed in mesenteric arteries of WT mice. |
|
|
|
| Publisher | | Wiley-Blackwell Publishing Ltd. |
| URL | | http://dx.doi.org/10.1111/j.1582-4934.2011.01457.x |
| DOI | | 10.1111/j.1582-4934.2011.01457.x |
|
|
Actions | |   |
