Frailty and the role of inflammation, immunosenescence and cellular ageing in the very old: Cross-sectional findings from the Newcastle 85+ Study

Dr Joanna Collerton; Dr Carmen Martin-Ruiz; karen Davies; Dr Catharien Hilkens; Professor John Isaacs; Claire Kolenda; Dr Craig Parker; Dr Michael Dunn; Professor Mike Catt; Professor Carol Jagger; Professor Thomas von Zglinicki; Professor Thomas Kirkwood CBE

Frailty and the role of inflammation, immunosenescence and cellular ageing in the very old: Cross-sectional findings from the Newcastle 85+ Study Lookup NU author(s) Dr Joanna Collerton Dr Carmen Martin-Ruiz karen Davies Dr Catharien Hilkens Professor John Isaacs Claire Kolenda Dr Craig Parker Dr Michael Dunn Professor Mike Catt Professor Carol Jagger Professor Thomas von Zglinicki Professor Thomas Kirkwood CBE



Author(s)		Collerton J, Martin-Ruiz C, Davies K, Hilkens CM, Isaacs J, Kolenda C, Parker C, Dunn M, Catt M, Jagger C, von Zglinicki T, Kirkwood TB
Publication type		Article
Journal		Mechanisms of Ageing and Development
Year		2012
Volume		133
Issue		6
Pages		456-466
ISSN (print)		0047-6374
ISSN (electronic)		1872-6216



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Age-related frailty is an increasing societal challenge with growing emphasis on identifying its underlying pathophysiology and prospects for intervention. We report findings from the first comprehensive study of frailty and biomarkers of inflammation, immunosenescence and cellular ageing in the very old. Using cross-sectional data from the Newcastle 85+ Study (n=845, aged 85), frailty was operationalized by the Fried and Rockwood models and biomarker associations explored using regression analysis. We confirmed the importance of inflammatory markers (IL-6, TNF-alpha, CRP, neutrophils) in frailty in the very old, previously established only in younger-old populations. Limited evidence was found for immunosenescence in frailty; although total lymphocyte count was inversely related, no association was found with the immune risk profile and the inverse associations observed with memory/naive CD8 T and B cell ratios were in the opposite direction to that expected. We found no association with frailty in the very old for CMV sero-positivity, telomere length, markers of oxidative stress or DNA damage and repair. The Fried and Rockwood frailty models measure different albeit overlapping concepts yet biomarker associations were generally consistent between models. Difficulties in operationalizing the Fried model, due to high levels of co-morbidity, limit its utility in the very old.



Publisher		Elsevier Ireland Ltd
URL		http://dx.doi.org/10.1016/j.mad.2012.05.005
DOI		10.1016/j.mad.2012.05.005
PubMed id		22663935
Notes		Collerton, Joanna Martin-Ruiz, Carmen Davies, Karen Hilkens, Catharien M Isaacs, John Kolenda, Claire Parker, Craig Dunn, Michael Catt, Michael Jagger, Carol von Zglinicki, Thomas Kirkwood, Thomas B L Ireland Mech Ageing Dev. 2012 Jun;133(6):456-66. Epub 2012 Jun 1.

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