Vitamin D in children with cystic fibrosis

  1. Lookup NU author(s)
  2. Dr Malcolm Brodlie
  3. Dr Matthew Thomas
  4. Dr David Spencer
Author(s)Brodlie M, Orchard WA, Reeks GA, Pattman S, McCabe H, O'Brien CJ, Thomas MF, Spencer DA
Publication type Article
JournalArchives of Disease in Childhood
ISSN (print)0003-9888
ISSN (electronic)1468-2044
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Purpose The Cystic Fibrosis Trust in 2007 published a recommended target of 75-150 nmol/L for 25-hydroxyvitamin D (25-OHD). In 2008 we found that only 10% of pancreatic insufficient (PI) children met this target. An increase in supplementation was implemented and a repeat audit performed in 2010.Methods PI children ≥1 year under sole-care in our regional centre were included. Vitamin D3 supplementation increased by >450% to either 3800 IU/day liquid or 800 IU daily plus 20,000 IU weekly tablets. In 2010 pancreatic sufficient (PS) children were also audited separately.Results The median 25-OHD level increased from 51.5 nmol/L in 2008 (n=78, 10% >75 nmol/L) to 72 nmol/L in 2010 (n=72, 51% >75 nmol/L), p<0.0001. In PS children (n=15 in 2010) 87% had 25-OHD levels <75 nmol/L.Conclusions A substantial increase in supplementation led to a significant increase in 25-OHD levels but around half still failed to reach the recommended target.
PublisherBMJ Group
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