Mitochondrial pharma-Q-genomics: Targeting the OXPHOS cytochrome b

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  2. Dr Aurora Gomez Duran
Author(s)Gómez-Durán A, Pacheu-Grau D, López-Pérez MJ, Montoya J, Ruíz-Pesini E
Publication type Article
JournalDrug Discovery Today
Year2011
Volume16
Issue5-6
Pages176-180
ISSN (print)1359-6446
ISSN (electronic)1878-5832
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Genetic variation in human cytochrome b generates structurally different coenzyme Q binding pockets, affects the coupling efficiency of the oxidative phosphorylation system and susceptibility to different medical conditions. As modification of coupling efficiency has already been shown to have therapeutic interest, these structural differences might be used to develop new drugs and allow for personalized medicine, giving rise to a new field: mitochondrial pharmacogenomics.
PublisherElsevier
URLhttp://dx.doi.org/10.1016/j.drudis.2010.11.010
DOI10.1016/j.drudis.2010.11.010
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