Bimodal collagen fibril diameter distributions direct age-related variations in tendon resilience and resistance to rupture

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  2. Dr Kheng-Lim Goh
Author(s)Goh KL, Holmes DF, Lu Y-H, Purslow PP, Kadler KE, Bechet D, Wess TJ
Publication type Article
JournalJournal of Applied Physiology
Year2012
Volume113
Issue6
Pages878-888
ISSN (print)8750-7587
ISSN (electronic)1522-1601
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Scaling relationships have been formulated to investigate the influence of collagen fibril diameter (D) on age-related variations in the strain energy density of tendon. Transmission electron microscopy was used to quantify D in tail tendon from 1.7- to 35.3-mo-old (C57BL/6) male mice. Frequency histograms ofD for all age groups were modeled as two normally distributed subpopulations with smaller (DD1) and larger (DD2) mean Ds, respectively. Both DD1 and DD2increase from 1.6 to 4.0 mo but decrease thereafter. From tensile tests to rupture, two strain energy densities were calculated: 1) uE [from initial loading until the yield stress (σY)], which contributes primarily to tendon resilience, and 2) uF[from σY through the maximum stress (σU) until rupture], which relates primarily to resistance of the tendons to rupture. As measured by the normalized strain energy densities uEY and uFU, both the resilience and resistance to rupture increase with increasing age and peak at 23.0 and 4.0 mo, respectively, before decreasing thereafter. Multiple regression analysis reveals that increases in uEY(resilience energy) are associated with decreases in DD1 and increases in DD2, whereas uFU (rupture energy) is associated with increases in DD1 alone. These findings support a model where age-related variations in tendon resilience and resistance to rupture can be directed by subtle changes in the bimodal distribution of Ds.
PublisherAmerican Physiological Society
URLhttp://dx.doi.org/10.1152/japplphysiol.00258.2012
DOI10.1152/japplphysiol.00258.2012
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