Default network is not hypoactive in dementia with fluctuating cognition: an Alzheimer disease/dementia with Lewy bodies comparison

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  2. Dr John-Paul Taylor
Author(s)Franciotti R, Falasca NW, Bonanni L, Anzellottia F, Maruottia V, Comania S, Thomas A, Tartaroa A, Taylor J-P, Onofrj M
Publication type Article
JournalNeurobiology of Ageing
Year2013
Volume34
Issue4
Pages1148-1158
ISSN (print)0197-4580
ISSN (electronic)1558-1497
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Default mode network resting state activity in posterior cingulate cortex is abnormally reduced in Alzheimer disease (AD) patients. Fluctuating cognition and electroencephalogram abnormalities are established core and supportive elements respectively for the diagnosis of dementia with Lewy bodies (DLB). Our aim was to assess whether patients with DLB with both of these features have different default mode network patterns during resting state functional magnetic resonance imaging compared with AD. Eighteen patients with DLB, 18 AD patients without fluctuating cognition, and 15 control subjects were selected after appropriate matching and followed for 2–5 years to confirm diagnosis. Independent component analysis with functional connectivity (FC) and Granger causality approaches were applied to isolate and characterize resting state networks. FC was reduced in AD and DLB patients compared with control subjects. Posterior cingulate cortex activity was lower in AD than in control subjects and DLB patients (p < 0.05). Right hemisphere FC was reduced in DLB patients in comparison with control subjects but not in patients with AD, and was correlated with severity of fluctuations (ρ = −0.69; p < 0.01). Causal flow analysis showed differences between patients with DLB and AD and control subjects.
PublisherElsevier Inc.
URLhttp://dx.doi.org/10.1016/j.neurobiolaging.2012.09.015
DOI10.1016/j.neurobiolaging.2012.09.015
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