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Identification and characterisation of STMN4 and ROBO2 gene involvement in neuroblastoma cell differentiation

Lookup NU author(s): Nidal Boulos, Dr Michael Tilby, Professor Deborah Tweddle, Professor John LunecORCiD

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Abstract

To better understand neuroblastoma differentiation, we used microarray analysis to identify common gene expression changes from three differentiation models. This revealed STMN4 and ROBO2 to be consistently up-regulated in differentiated neuroblastoma cells induced by chromosome 1 transfer, MYCN knockdown, and 9-cis retinoic acid (9cRA). Furthermore, stable expression of transfected STMN4 or ROBO2 induced differentiation in IMR-32 cells. STMN4 and ROBO2 expression also increased in other 9cRA-induced differentiated neuroblastoma cell lines. Of clinical importance is that neuroblastoma patients with higher tumour mRNA expression of STMN4 and ROBO2 had better progression-free survival. This study highlights the importance of STMN4 and ROBO2 during neuroblastoma differentiation. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

Publication metadata

Author(s): Sung PJ, Boulos N, Tilby MJ, Andrews WD, Newbold RF, Tweddle DA, Lunec J

Publication type: Article

Publication status: Published

Journal: Cancer Letters

Year: 2013

Volume: 328

Issue: 1

Pages: 168-175

Print publication date: 01/01/2013

ISSN (print): 0304-3835

ISSN (electronic): 1872-7980

Publisher: Elsevier

URL: http://dx.doi.org/10.1016/j.canlet.2012.08.015

DOI: 10.1016/j.canlet.2012.08.015

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