Regulation of gene expression by the RNA-binding protein Sam68 in cancer

  1. Lookup NU author(s)
  2. Dr Prabhakar Rajan
  3. Dr Luke Gaughan
  4. Caroline Dalgliesh
  5. Dr Amira El-Sherif
  6. Professor Craig Robson
  7. Professor Hing Leung
  8. Professor David Elliott
Author(s)Rajan P, Gaughan L, Dalgliesh C, El-Sherif A, Robson CN, Leung HY, Elliott DJ
Publication type Article
JournalBiochemical Society Transactions
ISSN (print)0300-5127
ISSN (electronic)1470-8752
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Sam68 (Src-associated in mitosis 68 kDa) is the prototypical member of the STAR (signal transducer and activator of RNA) family of RNA-binding proteins. Sam68 is implicated in a number of cellular processes including signal transduction, transcription, RNA metabolism, cell cycle regulation and apoptosis. In the present review, we summarize the functions of Sam68 as a transcriptional and post-transcriptional regulator of gene expression, with particular relevance to cancer.
PublisherPortland Press Ltd.
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