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Regulation of gene expression by the RNA-binding protein Sam68 in cancer
Lookup NU author(s)
Dr Prabhakar Rajan
Dr Luke Gaughan
Dr Amira El-Sherif
Professor Craig Robson
Professor Hing Leung
Professor David Elliott
Rajan P, Gaughan L, Dalgliesh C, El-Sherif A, Robson CN, Leung HY, Elliott DJ
Biochemical Society Transactions
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Sam68 (Src-associated in mitosis 68 kDa) is the prototypical member of the STAR (signal transducer and activator of RNA) family of RNA-binding proteins. Sam68 is implicated in a number of cellular processes including signal transduction, transcription, RNA metabolism, cell cycle regulation and apoptosis. In the present review, we summarize the functions of Sam68 as a transcriptional and post-transcriptional regulator of gene expression, with particular relevance to cancer.
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