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Efavirenz induced acute liver failure requiring liver transplantation in a slow drug metaboliser

Lookup NU author(s): Dr Ahmed Elsharkawy, Dr Ulrich Schwab, Dr Brendan McCarron, Professor Alastair BurtORCiD, Professor Ann DalyORCiD, Dr Steven MassonORCiD

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Abstract

Highly active antiretroviral therapy has revolutionised HIV management. However, many of these drugs are potentially hepatotoxic. Here, we report the first adult case of efavirenz induced acute liver failure successfully treated by liver transplantation. Furthermore, genetic analysis revealed our patient to be a slow efavirenz metaboliser, contributing to the severity of clinical presentation. (C) 2013 Elsevier B. V. All rights reserved.

Publication metadata

Author(s): Elsharkawy AM, Schwab U, McCarron B, Burt AD, Daly AK, Hudson M, Masson S

Publication type: Article

Publication status: Published

Journal: Journal of Clinical Virology

Year: 2013

Volume: 58

Issue: 1

Pages: 331-333

Print publication date: 11/06/2013

ISSN (print): 1386-6532

ISSN (electronic): 1873-5967

Publisher: Elsevier BV

URL: http://dx.doi.org/10.1016/j.jcv.2013.05.003

DOI: 10.1016/j.jcv.2013.05.003

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