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Assessment of sleep and circadian rhythm disorders in the very old: the Newcastle 85+ Cohort Study

Lookup NU author(s): Dr Kirstie Anderson, Professor Mike Catt, Dr Joanna Collerton, Dr Karen Davies, Professor Thomas von Zglinicki, Emeritus Professor Thomas Kirkwood, Emerita Professor Carol Jagger

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Abstract

Objectives: to examine the association between subjective and objective measures of sleep and wake and other health parameters in a cohort of the very old.Design: a population-based cohort study.Setting: primary care, North East England.Participants: four hundred and twenty-one men and women, aged 87-89, recruited to the Newcastle 85+ Study cohort.Methods: sleep questionnaires were administered and sleep-wake patterns were assessed over 5-7 days with a novel wrist triaxial accelerometer. Associations between sleep measures and various health parameters, including mortality at 24 months, were examined.Results: only 16% of participants perceived their sleep as severely disturbed as assessed with questionnaire responses. Wrist accelerometry showed marked variation between normal and abnormal sleep-wake cycles that did not correlate with the participants' perception of sleep. Impaired sleep-wake cycles were significantly associated with cognitive impairment, disability, depression, increased falls, body mass index and arthritis but not with any other specific disease markers and with decreased survival.Conclusions: commonly used sleep questionnaires do not differentiate well between those with objectively determined disturbance of sleep-wake cycles and those with normal cycles. Abnormal sleep-wake patterns are associated with institutionalisation, cognitive impairment, disability, depression and arthritis but not with other diseases; there is also an association with reduced survival.

Publication metadata

Author(s): Anderson KN, Catt M, Collerton J, Davies K, von Zglinicki T, Kirkwood TBL, Jagger C

Publication type: Article

Publication status: Published

Journal: Age and Ageing

Year: 2014

Volume: 43

Issue: 1

Pages: 57-63

Print publication date: 11/10/2013

ISSN (print): 0002-0729

ISSN (electronic): 1468-2834

Publisher: Oxford University Press

URL: http://dx.doi.org/10.1093/ageing/aft153

DOI: 10.1093/ageing/aft153

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