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Lookup NU author(s): Graciela Rocha, Dr Johnny RoughanORCiD, Dr Matthew Leach, Emeritus Professor Paul FlecknellORCiD, Professor Colin Ingram, Dr Kirsten BrandtORCiD
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The chemical profile and medicinal effects of H. crenata on two mouse models were evaluated in order to quantify pharmacological effects caused by bioactive compounds. A survey was conducted regarding traditional preparation and use of H. crenata in Brazil (20 regular users). The extraction methods reported were: (i) decoction (boiling in water); (ii) infusion (tea); (iii) cold extraction (water); (iv) cold extraction (15% alcohol); and (v) cold extraction (40% alcohol). The decoction extract (i) showed the highest concentration of dry matter (4.55 g/L). The traditional uses most frequently reported were for forms of mild pain (11/20 - headache, stomach discomfort, menstrual pain) or treatment of flu/fever (6/20). Based on this traditional use, a study was conducted on the antinociceptive effects of the decoction extract (i) in 8 C57/BL6 mice per treatment. Orally administered doses of 15 and 150 mg/kg b.w. were compared with water and Indomethacin 10 mg/kg b.w in models of phasic pain (Hargreaves test) and tonic pain (acetic acid-induced writhing). In both models the treatment effects were significantly different from the water control treatment, but not from the positive control Indomethacin. HPLC analysis of the decoction extract compared with an authentic standard of salicylic acid showed that salicylic acid was not detectable in the extract.
Author(s): Rocha GS, Roughan J, Leach M, Flecknell P, Ingram CD, Brandt K
Publication type: Conference Proceedings (inc. Abstract)
Publication status: Published
Conference Name: II International Symposium on Medicinal and Nutraceutical Plants
Year of Conference: 2013
Pages: 105-110
Print publication date: 01/01/2013
Publisher: International Society for Horticultural Science
URL: http://www.ishs.org/ishs-book/972
Series Title: ISHS Acta Horticulturae
