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Lookup NU author(s): Professor John IsaacsORCiD, Professor Christopher Buckley
It is well established that an intimate connection exists between inflammation and neoplasia. Indeed, particular chronic infections and autoimmune processes giving rise to prolonged site-specific inflammation are known to increase the probability of the development of specific cancers. Molecular characterisation of these processes has revealed profound similarities in the specific molecules involved in persistence of inflammation and in both the primary induction of neoplastic processes and in specification of the preferred anatomic sites of metastatic spread. The therapeutic importance of these findings is underscored by the remarkable success in the treatment of autoimmune pathology using medications initially developed for use in oncology and this arena is one of considerable therapeutic promise for rheumatologists.
Author(s): Sherlock JP, Filer AD, Isaacs JD, Buckley CD
Publication type: Editorial
Publication status: Published
Journal: Arthritis Research & Therapy
Year: 2013
Volume: 15
Issue: 3
Online publication date: 01/05/2013
ISSN (print): 1478-6354
ISSN (electronic): 1478-6362
Publisher: BioMed Central Ltd
URL: http://dx.doi.org/10.1186/ar4203
DOI: 10.1186/ar4203
