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Bioinspired porous membranes containing polymer nanoparticles for wound healing
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Dr Ana Ferreira-Duarte
Ferreira AM, Mattu C, Ranzato E, Ciardelli G
Journal of Biomedical Materials Research - Part A
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Skin damages covering a surface larger than 4 cm2 require a regenerative strategy based on the use of appropriate wound dressing supports to facilitate the rapid tissue replacement and efficient self-healing of the lost or damaged tissue. In the present work, a novel biomimetic approach is proposed for the design of a therapeutic porous construct made of poly(l-lactic acid) (PLLA) fabricated by thermally induced phase separation (TIPS). Biomimicry of ECM was achieved by immobilization of type I collagen through a two-step plasma treatment for wound healing. Anti-inflammatory (indomethacin)-containing polymeric nanoparticles (nps) were loaded within the porous membranes in order to minimize undesired cell response caused by post-operative inflammation. The biological response to the scaffold was analyzed by using human keratinocytes cell cultures. In this work, a promising biomimetic construct for wound healing and soft tissue regeneration with drug-release properties was fabricated since it shows (i) proper porosity, pore size, and mechanical properties, (ii) biomimicry of ECM, and (iii) therapeutic potential
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