Familial neurocardiogenic (vasovagal) syncope

  1. Lookup NU author(s)
  2. Professor Julia Newton
  3. Dr Simon Kerr
  4. Jessie Pairman
  5. Dr Andrew McLaren
  6. Professor Rose Anne Kenny
  7. Dr Christopher Morris
Author(s)Newton JL, Kerr S, Pairman J, McLaren A, Norton M, Kenny RA, Morris CM
Publication type Article
JournalAmerican Journal of Medical Genetics: Part A
Year2005
Volume133
Issue2
Pages176-179
ISSN (print)1552-4825
ISSN (electronic)1552-4833
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Vasovagal syncope (VSS) is an exaggerated tendency towards the common faint caused by a sudden and profound hypotension with or without bradycardia. The etiology of VVS is unknown though several lines of evidence indicate central and peripheral abnormalities of sympathetic function. Studies however indicate a strong heritable component to the etiology of VVS in over 20% of cases. Here, we report the findings from a family that shows apparently autosomal dominant VVS in at least three generations. Clinical findings included an absence of any discernible cardiac or autonomic abnormalities and reproducible hypotension on tilt table testing in affected family members.
PublisherJohn Wiley & Sons, Inc.
URLhttp://onlinelibrary.wiley.com/doi/10.1002/ajmg.a.30572/pdf
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