ePrints

Summary of Results and Discussions From the Gene-Based Tests Group at Genetic Analysis Workshop 18

Lookup NU author(s): Professor Heather Cordell

Downloads

• Published version [.pdf]

Licence

This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

Abstract

I present a summary of the results and discussions held within the working group on gene-based tests at Genetic Analysis Workshop 18 (GAW18). The main focus of interest in our working group was modeling the action of combinations or " groups" of genetic variants, with a group of variants most often defined as a set of single-nucleotide polymorphisms lying within a known gene. Some contributions investigated the performance of previously proposed methods (particularly rare variant collapsing or burden-type methods) for addressing this question, applied to the GAW18 data, and other contributions developed novel approaches and addressed novel questions. Most approaches were successful in detecting significant effects at MAP4 in the simulated data. No other genetic effects were consistently detected across different analyses. Low power was noted, particularly for those methods that restricted analysis to purely the subset of unrelated individuals. (C) 2014 Wiley Periodicals, Inc.

Publication metadata

Author(s): Cordell HJ

Publication type: Article

Publication status: Published

Journal: Genetic Epidemiology

Year: 2014

Volume: 38

Issue: Suppl. 1

Pages: S44-S48

Print publication date: 01/09/2014

Online publication date: 11/08/2014

Date deposited: 10/10/2014

ISSN (print): 0741-0395

ISSN (electronic): 1098-2272

Publisher: Wiley-Blackwell

URL: http://dx.doi.org/10.1002/gepi.21824

DOI: 10.1002/gepi.21824

Altmetrics

Funding

Share