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Lookup NU author(s): Professor Anthony De SoyzaORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Pseudomonas aeruginosa is a major opportunistic pathogen in cystic fibrosis (CF) patients and causes a wide range of infections among other susceptible populations. Its inherent resistance to many antimicrobials also makes it difficult to treat infections with this pathogen. Recent evidence has highlighted the diversity of this species, yet despite this, the majority of studies on virulence and pathogenesis focus on a small number of strains. There is a pressing need for a P. aeruginosa reference panel to harmonize and coordinate the collective efforts of the P. aeruginosa research community. We have collated a panel of 43 P. aeruginosa strains that reflects the organism's diversity. In addition to the commonly studied clones, this panel includes transmissible strains, sequential CF isolates, strains with specific virulence characteristics, and strains that represent serotype, genotype or geographic diversity. This focussed panel of P. aeruginosa isolates will help accelerate and consolidate the discovery of virulence determinants, improve our understanding of the pathogenesis of infections caused by this pathogen, and provide the community with a valuable resource for the testing of novel therapeutic agents.
Author(s): De Soyza A; Hall AJ; Mahenthiralingam E; Drevinek P; Kaca W; Drulis-Kawa Z; Stoitsova SR; Toth V; Coenye T; Zlosnik JEA; Burns JL; Sa-Correia I; De Vos D; Pirnay JP; Kidd TJ; Reid D; Manos J; Klockgether J; Wiehlmann L; Tummler B; McClean S; Winstanley C
Publication type: Article
Publication status: Published
Journal: MicrobiologyOpen
Year: 2013
Volume: 2
Issue: 6
Pages: 1010-1023
Print publication date: 01/12/2013
Online publication date: 11/11/2013
Date deposited: 08/01/2016
ISSN (electronic): 2045-8827
Publisher: Wiley-Blackwell
URL: http://dx.doi.org/10.1002/mbo3.141
DOI: 10.1002/mbo3.141
Notes: On behalf of EU FP7 funded COST Action BM1003 "Cell surface virulence determinants of cystic fibrosis pathogens"
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