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Lookup NU author(s): Professor Francisco FigueiredoORCiD
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This report presents the results of a systematic review and meta-analyses of studies on epithelium-off photochemical corneal collagen cross-linkage for the management of keratoconus and secondary ectasia. The literature search identified 3,400 records of which 49 were considered for inclusion in the meta-analyses. Eight papers reported 4 unique randomized controlled trials, 29 studies were prospective, and 12 were retrospective studies. The majority of the studies (39/49) were graded as very low quality evidence. Twenty-six studies described adverse events and were included in the safety analysis. Meta-analyses are presented for changes in four outcomes: visual acuity, topography, refraction and astigmatism, and central corneal thickness. Statistically significant improvements were found in all efficacy outcomes at 12 months after the operation. Common side effects were pain, corneal edema, and corneal haze, which resolved usually within a few days after the procedure. The remaining uncertainty is duration of benefit to establish the procedure's potential benefit in avoiding or delaying disease progression and possibly reducing the need for corneal transplantation.
Author(s): Craig JA, Mahon J, Yellowlees A, Barata T, Glanville J, Arber M, Mandava L, Powell J, Figueiredo F
Publication type: Review
Publication status: Published
Journal: The Ocular Surface
Year: 2014
Volume: 12
Issue: 3
Pages: 202-214
Print publication date: 01/07/2014
Online publication date: 14/05/2014
Acceptance date: 02/05/2014
ISSN (print): 1542-0124
ISSN (electronic): 1937-5913
Publisher: ELSEVIER SCIENCE BV
URL: http://dx.doi.org/10.1016/j.jtos.2014.05.002
DOI: 10.1016/j.jtos.2014.05.002
PubMed id: 24999102
