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Lookup NU author(s): Professor Mary Slatter, Professor Roderick Skinner
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Graft-versus-host disease (GvHD) remains a significant hurdle in overcoming the morbidity and mortality associated with haemopoietic stem cell transplantation in children. Better understanding of its pathobiology is facilitating the development of biomarkers for the severity of acute GvHD and treatment response, and has led to the introduction of a more prognostically relevant grading system for chronic GvHD. These enable stratification of appropriate prophylactic and treatment strategies according to the risk profiles of individual patients. Steroid-refractory acute GvHD has a poor prognosis, but early reports of the use of new immunosuppressive drugs and especially cellular treatments with extracorporeal photopheresis and mesenchymal stem cells suggest improved short-term outcomes and offer the promise of increased longer-term survival rates.
Author(s): Dhir S, Slatter M, Skinner R
Publication type: Review
Publication status: Published
Journal: Archives of Disease in Childhood
Year: 2014
Volume: 99
Issue: 12
Pages: 1150-1157
Print publication date: 01/12/2014
Online publication date: 12/07/2014
Acceptance date: 23/06/2014
ISSN (print): 0003-9888
ISSN (electronic): 1468-2044
Publisher: BMJ PUBLISHING GROUP
URL: http://dx.doi.org/10.1136/archdischild-2013-304832
DOI: 10.1136/archdischild-2013-304832