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Lookup NU author(s): Professor Philip Sloan, Dr Max RobinsonORCiD
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Objectives/HypothesisThe incidence of human papillomavirus (HPV)-driven disease beyond the oropharynx varies greatly in the reported literature.Study DesignCase series.MethodsTwo hundred twenty-one samples were strictly classified to the subsites of oral cavity, larynx, or hypopharynx at the time of primary surgery. Formalin-fixed paraffin-embedded samples were subjected to a validated, tiered, diagnostic algorithm of p16 immunohistochemistry, high-risk HPV in situ hybridization, and quantitative polymerase chain reaction for HPV E6 DNA. An additional 60 oropharyngeal cases acted as an internal biological control.ResultsAn incidence of 4% of HPV-driven cases was observed across the subsites outside the oropharynx compared to 70% of tumors confined within it.ConclusionsThis is the first reporting of a broad range of nonoropharyngeal HPV rates using this validated diagnostic algorithm. It remains unclear whether patients with HPV-driven disease originating outside the oropharynx enjoy the same survival advantage apparent in those patients with oropharyngeal squamous cell carcinomas.Level of Evidence4 Laryngoscope, 124:2739-2744, 2014
Author(s): Upile NS, Shaw RJ, Jones TM, Goodyear P, Liloglou T, Risk JM, Boyd MT, Sheard J, Sloan P, Robinson M, Schache AG
Publication type: Article
Publication status: Published
Journal: Laryngoscope
Year: 2014
Volume: 124
Issue: 12
Pages: 2739-2744
Print publication date: 01/12/2014
Online publication date: 18/07/2014
Acceptance date: 16/06/2014
ISSN (print): 0023-852X
ISSN (electronic): 1531-4995
Publisher: John Wiley & Sons, Inc.
URL: http://dx.doi.org/10.1002/lary.24828
DOI: 10.1002/lary.24828
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