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BacillusRegnet: a transcriptional regulation database and analysis platform for Bacillus species

Lookup NU author(s): Dr Goksel Misirli, Dr Jennifer Hallinan, Professor Anil Wipat

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Abstract

As high-throughput technologies become cheaper and easier to use, raw sequence data and corresponding annotations for many organisms are becoming available. However, sequence data alone is not sufficient to explain the biological behaviour of organisms, which arises largely from complex molecular interactions. There is a need to develop new platform technologies that can be applied to the investigation of whole-genome datasets in an efficient and cost-effective manner. One such approach is the transfer of existing knowledge from well-studied organisms to closely-related organisms. In this paper, we describe a system, BacillusRegNet, for the use of a model organism, Bacillus subtilis, to infer genome-wide regulatory networks in less well-studied close relatives. The putative transcription factors, their binding sequences and predicted promoter sequences along with annotations are available from the associated BacillusRegNet website (http://bacillus.ncl.ac.uk).10.2390/biecoll-jib-2014-244

Publication metadata

Author(s): Misirli G, Hallinan J, Röttger R, Baumbach J, Wipat A

Publication type: Article

Publication status: Published

Journal: Journal of Integrative Bioinformatics

Year: 2014

Volume: 11

Issue: 2

Online publication date: 08/07/2014

ISSN (electronic): 1613-4516

Publisher: IMBIO e.V.

URL: http://dx.doi.org/10.2390/biecoll-jib-2014-244

DOI: 10.2390/biecoll-jib-2014-244

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