Small-molecule MDM2-p53 inhibitors: recent advances

  1. Lookup NU author(s)
  2. Bian Zhang
  3. Professor Bernard Golding
  4. Dr Ian Hardcastle
Author(s)Zhang B, Golding BT, Hardcastle IR
Publication type Review
JournalFuture Medicinal Chemistry
Year2015
Volume7
Issue5
Pages631-645
ISSN (print)1756-8919
ISSN (electronic)1756-8927
Full text is available for this publication:
Potent and selective small-molecule inhibitors of the p53-MDM2 interaction intended for the treatment of p53 wild-type tumors have been designed and optimized in a number of chemical series. This review details recent disclosures of compounds in advanced optimization and features key series that have given rise to clinical trial candidates. The structure–activity relationships for inhibitor classes are discussed with reference to x-ray structures, and common structural features are identified.
URLhttp://dx.doi.org/10.4155/fmc.15.13
DOI10.4155/fmc.15.13
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