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Variation in complement protein C1q is not a major contributor to cognitive impairment in Parkinson's disease

Lookup NU author(s): Dr Jennifer Duff, Professor Alison Yarnall, Professor David Burn, Professor Gavin Hudson

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).

Abstract

Traditional dogma regarding the brain as an immune exempt organ has changed in recent years. New research has highlighted the role of the classical complement cascade in both synaptic elimination and function, driven largely by the role of the pathway initiating protein C1q. Given the links between C1q and cognitive function we assessed the genetic variability of the C1q encoding genes: C1QA, C1QB and C1QC between PD patients and matched controls. Despite a strong link between C1Q/cognitive decline and PD/cognitive decline we were unable to find a link between common C1Q variation and PD. We conclude that common C1Q-A/B/C genetic variation is unlikely to contribute to cognitive decline or the missing heritability in PD. (C) 2015 The Authors. Published by Elsevier Ireland Ltd.

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Author(s): Carbutt S, Duff J, Yarnall A, Burn DJ, Hudson G

Publication type: Article

Publication status: Published

Journal: Neuroscience Letters

Year: 2015

Volume: 594

Pages: 66-69

Print publication date: 06/05/2015

Online publication date: 26/03/2015

Acceptance date: 24/03/2015

Date deposited: 09/06/2015

ISSN (print): 0304-3940

ISSN (electronic): 1872-7972

Publisher: Elsevier

URL: http://dx.doi.org/10.1016/j.neulet.2015.03.048

DOI: 10.1016/j.neulet.2015.03.048

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