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Biomimetic polyurethane - Based fibrous scaffolds
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Dr Piergiorgio Gentile
Tonda-Turo C, Boffito M, Cassino C, Gentile P, Ciardelli G
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The design of biomimetic scaffolds that reproduce the biochemical, mechanical and structural functions of the ECM is a fundamental requirement to develop functional substrate for tissue engineering. To this aim, materials which combine the easy processability and mechanical properties of synthetic polymers with the biochemical cues provided by natural materials, develop positive interaction with cells, enabling tissue regrowth in vivo. In this work, a polyester urethane (NS-BC2000) was synthesised using poly (ε-caprolactone) diol (PCL) as macrodiol, 1,4-diisocyanatobutane (BDI) as diisocyanate and N-Boc serinol as chain extender. After Boc cleavage (S-BC2000) to expose free amino groups, a S-BC2000/PEO (80/20 wt./wt.) solution was successfully electrospun fabricating aligned nanofibres with a fibre size of 2.8±0.6 µm.
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