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Cognitive-behavioural therapy for patients with schizophrenia: a multicentre randomized controlled trial in Beijing, China

Lookup NU author(s): Professor Douglas Turkington

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Abstract

Background. Meta-analyses support the efficacy of cognitive-behavioural therapy (CBT) for schizophrenia in western cultures. This study aimed to compare the efficacy of CBT and supportive therapy (ST) for patients with schizophrenia in China.Method. A multicentre randomized controlled, single-blinded, parallel-group trial enrolled a sample of 192 patients with schizophrenia. All patients were offered 15 sessions of either CBT or ST over 24 weeks and followed up for an additional 60 weeks. All measures used were standardized instruments with good reliability and validity. The Positive and Negative Syndrome Scale (PANSS) was used to assess symptoms of schizophrenia. The Schedule for Assessing Insight (SAI) was used to assess patients' insight and the Personal and Social Performance Scale (PSP) was used to assess their social functioning.Results. Effect-size analysis showed that patients made rapid improvements in all symptoms, insight and social functioning as measured by the PANSS, SAI and PSP at 12 and 24 weeks and maintained these improvements over the course of the study to 84 weeks. Patients in the CBT group showed significantly greater and more durable improvement in PANSS total score (p = 0.045, between-group d = 0.48), positive symptoms (p = 0.018, between-group d = 0.42) and social functioning (p = 0.037, between-group d = 0.64), with significant differences emerging after completion of therapy.Conclusions. Both CBT and ST combined with medication had benefits on psychopathology, insight and social functioning of patients with schizophrenia. CBT was significantly more effective than ST on overall, positive symptoms and social functioning of patients with schizophrenia in the long term.


Publication metadata

Author(s): Li ZJ, Guo ZH, Wang N, Xu ZY, Qu Y, Wang XQ, Sun J, Yan LQ, Ng RMK, Turkington D, Kingdon D

Publication type: Article

Publication status: Published

Journal: Psychological Medicine

Year: 2015

Volume: 45

Issue: 9

Pages: 1893-1905

Print publication date: 01/07/2015

Online publication date: 23/12/2014

Acceptance date: 25/11/2014

ISSN (print): 0033-2917

ISSN (electronic): 1469-8978

Publisher: Cambridge University Press

URL: http://dx.doi.org/10.1017/S0033291714002992

DOI: 10.1017/S0033291714002992


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Funding

Funder referenceFunder name
BIBD-PXM2013_014226_07_000084Beijing Institute for Brain Disorders
D0906001040391Beijing Municipal Science & Technology Commission

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