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Patient-reported outcomes with lanreotide Autogel/Depot for carcinoid syndrome: An international observational study

Lookup NU author(s): Dr Petros Perros

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).


Abstract

Background: Lanreotide Autogel/Depot effectively controls symptoms in patients with carcinoid syndrome associated with neuroendocrine tumours. Data on patient -reported outcomes are sparse.Aim: To evaluate the effect of lanreotide on patient -reported outcomes (PROs) with carcinoid syndrome. Methods: This was an international, open -label, observational study of adults with neuroendocrine tumours and history of diarrhoea, receiving lanreotide for >3 months for relief of carcinoid syndrome symptoms. The primary PRO measure was satisfaction with diarrhoea control. Secondary PRO measures included severity, change in symptoms and impact on daily life of diarrhoea; and patient satisfaction with flushing control.Results: Of 273 patients enrolled, 76% were 'completely' or 'rather' satisfied with diarrhoea control; 79% reported improvement in diarrhoea with lanreotide. The proportion of patients with 'mild', 'minimal', or no diarrhoea' increased from 33% before treatment to 75% during treatment; 75% were unconcerned about the impact of diarrhoea on daily life. Satisfaction with flushing control amongst patients with significant flushing at treatment initiation was 73%.Conclusions: Lanreotide treatment was associated with improvements in symptoms as well as a range of PROs in patients with neuroendocrine tumours and carcinoid syndrome (ClinicalTrials.gov: NCT01234168). (C) 2016 The Authors. Published by Elsevier Ltd on behalf of Editrice Gastroenterologica Italiana S.r.l.


Publication metadata

Author(s): Ruszniewski P, Valle JW, Lombard-Bohas C, Cuthbertson DJ, Perros P, Holubec L, Delle Fave G, Smith D, Niccoli P, Maisonobe P, Atlan P, Caplin ME, SYMNET Study Grp

Publication type: Article

Publication status: Published

Journal: Digestive and Liver Disease

Year: 2016

Volume: 48

Issue: 5

Pages: 552-558

Print publication date: 01/05/2016

Online publication date: 15/01/2016

Acceptance date: 22/12/2015

Date deposited: 26/05/2016

ISSN (print): 1590-8658

ISSN (electronic): 1878-3562

Publisher: Elsevier

URL: http://dx.doi.org/10.1016/j.dld.2016.12.007

DOI: 10.1016/j.dld.2016.12.007


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