Regulation of urokinase receptor transcription by Ras- and Rho-family GTPases
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- Emel Okan
- Dr Peter Jones
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| Author(s) | | Okan E; Jones P; Muller SM |
| Publication type | | Article |
| Journal | | Biochemical & Biophysical Research Communications |
| Year | | 2000 |
| Volume | | 270 |
| Issue | | 3 |
| Pages | | 892-898 |
| ISSN (print) | | 0006-291X |
| ISSN (electronic) | | 1090-2104 |
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| Full text for this publication is not currently held within this repository. Alternative links are provided below where available. |
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| How cell adhesion is coordinated with extracellular proteolysis is a key question in understanding cell migration. Potentially, the small GTP-binding proteins that affect actin organisation and signal transduction may also regulate the expression of genes associated with extracellular proteolysis. We investigated the ability of Ras, Rac-1, Cdc42Hs, and RhoA to regulate transcription from the1.55-kb promoter region of the human urokinase plasminogen activator receptor (uPAR) gene. Constitutively active V12 H-Ras and Rho-A stimulated uPAR transcription while Cdc42Hs and Rac-1 did not. The use of Ras effector-loop mutants indicated that signalling via multiple Ras-effectors is necessary for the maximum activation of transcription. Copyright 2000 Academic Press. |
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| Publisher | | Academic Press |
| URL | | http://dx.doi.org/10.1006/bbrc.2000.2531 |
| DOI | | 10.1006/bbrc.2000.2531 |
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