Regulation of urokinase receptor transcription by Ras- and Rho-family GTPases

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  2. Emel Okan
  3. Dr Peter Jones
Author(s)Okan E; Jones P; Muller SM
Publication type Article
JournalBiochemical & Biophysical Research Communications
ISSN (print)0006-291X
ISSN (electronic)1090-2104
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How cell adhesion is coordinated with extracellular proteolysis is a key question in understanding cell migration. Potentially, the small GTP-binding proteins that affect actin organisation and signal transduction may also regulate the expression of genes associated with extracellular proteolysis. We investigated the ability of Ras, Rac-1, Cdc42Hs, and RhoA to regulate transcription from the1.55-kb promoter region of the human urokinase plasminogen activator receptor (uPAR) gene. Constitutively active V12 H-Ras and Rho-A stimulated uPAR transcription while Cdc42Hs and Rac-1 did not. The use of Ras effector-loop mutants indicated that signalling via multiple Ras-effectors is necessary for the maximum activation of transcription. Copyright 2000 Academic Press.
PublisherAcademic Press
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