Production of 17-O-demethyl-geldanamycin, a cytotoxic ansamycin polyketide, by Streptomyces hygroscopicus DEM20745

  1. Lookup NU author(s)
  2. Dr Bernhard Kepplinger
  3. Hadiza Isah
  4. Dr Mike Probert
  5. Emeritus Professor Bill Clegg
  6. Dr Corinne Wills
  7. Emeritus Professor Michael Goodfellow
  8. Professor Jeff Errington
  9. Dr Nicholas Allenby
  10. Dr Michael Hall
Author(s)Baksh A, Kepplinger B, Isah H, Probert MR, Clegg W, Wills C, Goodfellow M, Errington J, Allenby N, Hall MJ
Publication type Article
JournalNatural Product Research
ISSN (print)1478-6419
ISSN (electronic)1478-6427
Full text is available for this publication:
The actinomycete DEM20745, collected from non-rhizosphere soil adjacent to Paraserianthes falactaria trees (Cangkringan, Indonesia), is an efficient producer of the anticancer ansamycin polyketide 17-O-demethyl-geldanamycin (17-O-DMG), a biosynthetic precursor of the Hsp90 inhibitor geldanamycin (GDM). In DEM20745, 17-O-DMG is the major ansamycin product observed reaching a maximum titre of 17 mg/L in the fermentation broth. 17-O-DMG has significant potential for direct use in anticancer therapy and is a key starting material for the semi-synthesis of GDM analogues. This preferential biosynthesis of 17-O-DMG facilitates easy access to this important molecule and provides further insight the biosynthesis of the geldanamycins.
PublisherTaylor & Francis
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