Intra- and inter-network functional alterations in Parkinson's disease with mild cognitive impairment

  1. Lookup NU author(s)
  2. Dr Luis Peraza Rodriguez
  3. Dr Rachael Lawson
  4. Dr Gordon Duncan
  5. Dr Alison Yarnall
  6. Dr Michael Firbank
  7. Professor John O'Brien
  8. Professor David Brooks
  9. Professor David Burn
  10. Dr John-Paul Taylor
Author(s)Peraza LR, Nesbitt D, Lawson RA, Duncan GW, Yarnall AJ, Khoo TK, Kaiser M, Firbank MJ, O'Brien JT, Barker RA, Brooks DJ, Burn DJ, Taylor JP
Publication type Article
JournalHuman Brain Mapping
Year2017
Volume
Issue
Pagesepub ahead of print
ISSN (print)1065-9471
ISSN (electronic)1097-0193
Full text is available for this publication:
Mild cognitive impairment (MCI) is prevalent in 15%–40% of Parkinson's disease (PD) patients at diagnosis. In this investigation, we study brain intra- and inter-network alterations in resting state functional magnetic resonance imaging (rs-fMRI) in recently diagnosed PD patients and characterise them as either cognitive normal (PD-NC) or with MCI (PD-MCI). Patients were divided into two groups, PD-NC (N = 62) and PD-MCI (N = 37) and for comparison, healthy controls (HC, N = 30) were also included. Intra- and inter-network connectivity were investigated from participants' rs-fMRIs in 26 resting state networks (RSNs). Intra-network differences were found between both patient groups and HCs for networks associated with motor control (motor cortex), spatial attention and visual perception. When comparing both PD-NC and PD-MCI, intra-network alterations were found in RSNs related to attention, executive function and motor control (cerebellum). The inter-network analysis revealed a hyper-synchronisation between the basal ganglia network and the motor cortex in PD-NC compared with HCs. When both patient groups were compared, intra-network alterations in RSNs related to attention, motor control, visual perception and executive function were found. We also detected disease-driven negative synchronisations and synchronisation shifts from positive to negative and vice versa in both patient groups compared with HCs. The hyper-synchronisation between basal ganglia and motor cortical RSNs in PD and its synchronisation shift from negative to positive compared with HCs, suggest a compensatory response to basal dysfunction and altered basal-cortical motor control in the resting state brain of PD patients.
PublisherWiley
URLhttp://dx.doi.org/10.1002/hbm.23499
DOI10.1002/hbm.23499
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