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New Approaches to Investigate Drug-Induced Hypersensitivity

Lookup NU author(s): Dr Shaheda Ahmed, Professor Anne Dickinson

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Abstract

The workshop on "New Approaches to Investigate Drug-Induced Hypersensitivity" was held on June 5, 2014 at the Foresight Center, University of Liverpool. The aims of the workshop were to (1) discuss our current understanding of the genetic, clinical, and chemical basis of small molecule drug hypersensitivity, (2) highlight the current status of assays that might be developed to predict potential drug immunogenicity, and (3) identify the limitations, knowledge gaps, and challenges that limit the use of these assays and utilize the knowledge gained from the workshop to develop a pathway to establish new and improved assays that better predict drug-induced hypersensitivity reactions during the early stages of drug development. This perspective reviews the clinical and immuno-logical bases of drug hypersensitivity and summarizes various experts' views on the different topics covered during the meeting.

Publication metadata

Author(s): Ogese MO, Ahmed S, Alferivic A, Betts CJ, Dickinson A, Faulkner L, French N, Gibson A, Hirschfield GM, Kammuller M, Meng XL, Martin SF, Musette P, Norris A, Pirmohamed M, Park BK, Purcell AW, Spraggs CF, Whritenour J, Naisbitt DJ

Publication type: Article

Publication status: Published

Journal: Chemical Research in Toxicology

Year: 2017

Volume: 30

Issue: 1

Pages: 239-259

Print publication date: 17/01/2017

Online publication date: 02/11/2016

Acceptance date: 02/04/2016

ISSN (print): 0893-228X

ISSN (electronic): 1520-5010

Publisher: American Chemical Society

URL: http://dx.doi.org/10.1021/acs.chemrestox.6b00333

DOI: 10.1021/acs.chemrestox.6b00333

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