Browse by author
Lookup NU author(s): Dr Tina Biss
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
© 2016 Wolters Kluwer Health, Inc. All rights reserved.There is a lack of evidence-based guidance for the prevention and management of thrombosis in children and young people treated for acute lymphoblastic leukemia. To determine current UK practice, a survey was sent to 28 centers participating in the Medical Research Council UKALL 2011 trial. Marked variation in practice was noted. In total, 43% of centers defer central venous access device insertion until end of induction for treatment of low-risk disease. Central venous access devices are removed at the end of intensive blocks in 38% and end of treatment in 42%. Duration of anticoagulation for line-associated thrombosis is 6 weeks in 43% and 3 months in 33% and for cerebral sinovenous thrombosis is 3 months in 71% and 6 months in 24%. Platelet transfusion to maintain platelet count >50×109/L, in preference to interrupting therapeutic anticoagulation, is used by 50% for line-associated thrombosis and 73% for cerebral sinovenous thrombosis. Conformity of practice was seen in some areas. In total, 70% treat thrombosis with twice-daily low-molecular weight heparin and 86% monitor antifactor Xa activity levels. In total, 91% reexpose individuals to asparaginase following a thrombotic event. Given this variation in practice, in the absence of highquality evidence, consensus guidelines may be helpful.
Author(s): Biss TT, Payne JH, Hough RE, Grainger JD, Macartney C, Sibson KR, Chalmers EA
Publication type: Article
Publication status: Published
Journal: Journal of Pediatric Hematology/Oncology
Year: 2016
Volume: 38
Issue: 3
Pages: 221-226
Online publication date: 01/04/2016
Acceptance date: 23/01/2016
ISSN (print): 1077-4114
ISSN (electronic): 1536-3678
Publisher: Lippincott Williams and Wilkins
URL: http://doi.org/10.1097/MPH.0000000000000538
DOI: 10.1097/MPH.0000000000000538
PubMed id: 26907659
Altmetrics provided by Altmetric
