Grip strength and inflammatory biomarker profiles in very old adults

  1. Lookup NU author(s)
  2. Dr Antoneta Granic
  3. Dr Karen Davies
  4. Dr Carmen Martin-Ruiz
  5. Professor Carol Jagger
  6. Emeritus Professor Thomas Kirkwood
  7. Professor Thomas von Zglinicki
  8. Professor Avan Aihie Sayer
Author(s)Granic A, Davies K, Martin-Ruiz C, Jagger C, Kirkwood TBL, von Zglinicki T, Sayer AA
Publication type Article
JournalAge and Ageing
PagesEpub ahead of print
ISSN (print)0002-0729
ISSN (electronic)1468-2834
Full text is available for this publication:
Background: weak grip strength (GS) and chronic inflammation have been implicated in the aetiology of sarcopenia in older adults. Given the interrelationships between inflammatory biomarkers, a summary variable may provide better insight into the relationship between inflammation and muscle strength. This approach has not been investigated in very old adults (aged ≥85) who are at highest risk of muscle weakness. Methods: we used mixed models to explore the prospective association between GS over 5 years in 845 participants in the Newcastle 85+ Study, and inflammatory components identified by principal component analysis (PCA). Cut-offs of ≤27 kg (men) and ≤16 (women) were used to define sub-cohorts with weak and normal GS at each assessment. Results: PCA identified 3 components, which explained 70% of the total variance in 7 baseline biomarkers. Basal interleukin-6 (IL-6) and tumor necrosis factor (TNF-α) had the highest loadings on Component 1; stimulated IL-6 and TNF-α and homocysteine the highest on Component 2; high-sensitivity C-reactive protein (hsCRP) loaded positively and albumin negatively to Component 3. In adjusted mixed models, only Component 3 was associated with GS. One SD increase of Component 3 was associated with a 0.41 kg lower GS initially (P = 0.03) in all participants, but not with GS decline over time. Similar conclusions held for those in the weak and normal GS sub-cohorts. Conclusion: an inflammatory profile including hsCRP and albumin was independently associated with baseline GS. Future studies linking inflammatory profiles and muscle strength are needed to corroborate these findings in older adults.
PublisherOxford University Press
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