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Poor Sleep Quality and Progression of Gait Impairment in an Incident Parkinson’s Disease Cohort

Lookup NU author(s): Dr Sean O'Dowd, Dr Brook Galna, Dr Rosie Morris, Dr Rachael LawsonORCiD, Dr Claire McDonald, Professor Alison Yarnall, Professor David Burn, Professor Lynn RochesterORCiD, Dr Kirstie Anderson

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This is the authors' accepted manuscript of an article that has been published in its final definitive form by IOS Press, 2017.

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Abstract

Abnormal sleep may associate with cognitive decline in Parkinson’s disease (PD). Furthermore, sleep dysfunction may associate with worse motor outcome. We hypothesised that PD patients with poor quality sleep would have greater progression in gait dysfunction, due to structural and functional overlap in networks subserving sleep and gait regulation. 12 PD patients and 12 age-matched controls completed longitudinal follow-up over 36 months. Poor sleep efficiency and greater sleep fragmentation correlated significantly with progression of step-width variability, a gait characteristic mediated by postural control, providing evidence that poor sleep in PD is associated with a more rapid deterioration in gait.

Publication metadata

Author(s): O'Dowd S, Galna B, Morris R, Lawson RA, McDonald C, Yarnall AJ, Burn DJ, Rochester L, Anderson KN

Publication type: Article

Publication status: Published

Journal: Journal of Parkinson's Disease

Year: 2017

Volume: 7

Issue: 3

Pages: 465-470

Print publication date: 08/08/2017

Online publication date: 30/07/2017

Acceptance date: 11/06/2017

Date deposited: 18/07/2017

ISSN (print): 1877-7171

ISSN (electronic): 1877-718X

Publisher: IOS Press

URL: https://doi.org/10.3233/JPD-161062

DOI: 10.3233/JPD-161062

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