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Lookup NU author(s): Ying Yin, Dr Jinju Chen, Dr Tieying Yin, Dr Yazhou Wang
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
For the treatment of glioma and other central nervous system diseases, the one of the biggest challenges is that most therapeutic drugs cannot be delivered to the brain tumor tissue due to the blood-brain barrier. The goal of this manuscript is to construct a nanodelivery vehicle system with capabilities to overcome the blood-brain barrier for central nervous system administration. Doxorubicin as a model drug encapsulated in ganglioside GM1 micelles was able to achieve up to 9.33% loading efficiency and 97.05% encapsulation efficiency by orthogonal experimental design. The in vitro study demonstrated a slow and sustainable drug release in physiological conditions. In the cellular uptake studies, mixed micelles could effectively transport into both human umbilical vein endothelial cells and C6 cells. Furthermore, biodistribution imaging of mice showed that the DiR /GM1 mixed micelles were accumulated sustainably and distributed centrally in the brain. Experiments on zebrafish confirmed that drug-loaded GM1 micelles can overcome the blood-brain barrier and enter the brain. Among all the treatment groups, the median survival time of C6 bearing rats after administering DOX/GM1 micelles was significantly prolonged. In conclusion, the ganglioside nano micelles developed in this work can not only penetrate BBB effectively, but also can repair nerves and kill tumor cells at the same time.
Author(s): Zou D, Wang W, Lei D, Yin Y, Ren P, Chen J, Yin T, Wang B, Wang G, Wang Y
Publication type: Article
Publication status: Published
Journal: International Journal of Nanomedicine
Year: 2017
Volume: 12
Pages: 4879-4889
Online publication date: 07/07/2017
Acceptance date: 07/06/2017
Date deposited: 18/07/2017
ISSN (print): 1176-9114
ISSN (electronic): 1178-2013
Publisher: Dove Medical Press Ltd.
URL: https://doi.org/10.2147/IJN.S138257
DOI: 10.2147/IJN.S138257
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