When nonsense makes sense and vice versa: Noncanonical decoding events at stop codons in eukaryotes
- Lookup NU author(s)
- Dr Victoriya Doronina
- Dr Jeremy Brown
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| Author(s) | | Doronina VA, Brown JD |
| Publication type | | Review |
| Journal | | Molecular Biology |
| Year | | 2006 |
| Volume | | 40 |
| Issue | | 4 |
| Pages | | 654-663 |
| ISSN (print) | | 0026-8933 |
| ISSN (electronic) | | 1608-3245 |
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| Full text for this publication is not currently held within this repository. Alternative links are provided below where available. |
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| Abstract —Regulation of protein synthesis at the level of translation termination is a relatively underexplored, but rapidly expanding field. Recent advances in elucidating the mechanism of translation termination are helping to understand noncanonical events associated with translation termination. These “recoding” events include read-through of stop codons, insertion of unusual amino acids such as selenocysteine, and production of several polypeptides from one open reading frame. This review summarizes data on termination-dependent recoding events and proposes that there are two types of stop codon-associated sequences optimized to perform different functions: termination of translation per se or alternative elongation events |
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| URL | | http://dx.doi.org/10.1134/S0026893306040182 |
| DOI | | 10.1134/S0026893306040182 |
| PubMed id | | 16913232 |
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