When nonsense makes sense and vice versa: Noncanonical decoding events at stop codons in eukaryotes

  1. Lookup NU author(s)
  2. Dr Victoriya Doronina
  3. Dr Jeremy Brown
Author(s)Doronina VA, Brown JD
Publication type Review
JournalMolecular Biology
Year2006
Volume40
Issue4
Pages654-663
ISSN (print)0026-8933
ISSN (electronic)1608-3245
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Abstract —Regulation of protein synthesis at the level of translation termination is a relatively underexplored, but rapidly expanding field. Recent advances in elucidating the mechanism of translation termination are helping to understand noncanonical events associated with translation termination. These “recoding” events include read-through of stop codons, insertion of unusual amino acids such as selenocysteine, and production of several polypeptides from one open reading frame. This review summarizes data on termination-dependent recoding events and proposes that there are two types of stop codon-associated sequences optimized to perform different functions: termination of translation per se or alternative elongation events
URLhttp://dx.doi.org/10.1134/S0026893306040182
DOI10.1134/S0026893306040182
PubMed id16913232
Actions    Link to this publication
Share