About Open Access
Olanzapine-induced hyperglycaemic coma and neuroleptic malignant syndrome: case report and review of literature
Lookup NU author(s)
Dr Niraj Ahuja
Dr Paul Mackin
Dr Adrian Lloyd
Ahuja N, Palanichamy N, Mackin P, Lloyd A
Journal of Psychopharmacology
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Although the relationship between antipsychotic medication, particularly second-generation antipsychotics (SGAs), and metabolic disturbance is increasingly accepted, there is an important, but little recognised, potential interaction between this and the other important serious adverse effect of neuroleptic malignant syndrome (NMS). We report a case of a 35-year old female who developed new onset type II diabetes mellitus with hyperosmolar hyperglycaemic coma and acute renal failure following treatment with a SGA for a first manic episode. The history is strongly suggestive of concurrent NMS. This case raises important questions about non-ketotic, hyperosmolar diabetic coma with antipsychotics, the possible association between hyperglycaemia and hyperthermia, and the direction of causality in this, the recognition of either syndrome when they co-exist and management issues in such patients. These questions are considered in the context of currently available literature.
Sage Publications Ltd.
Newcastle University Library, NE2 4HQ, United Kingdom. Tel: 0044 (191) 222 7657
©2014 Newcastle University Library