About Open Access
An investigation of mitochondrial haplogroups in autism
Lookup NU author(s)
Dr Hannah Elliott
Dr Catherine Mowbray
Professor Patrick Chinnery
Kent L, Gallagher L, Elliott HR, Mowbray C, Chinnery PF
American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Family and twin studies provide strong evidence of a major genetic influence in autism, but the underlying gene defects have yet to be characterized. The mothers of boys with autism share autistic traits, raising the possibility of a maternally inherited factor. Mitochondrial DNA (mtDNA) is almost exclusively inherited down the maternal line. We therefore explored the possibility that a particular mtDNA lineage contributes to the risk of developing autism. The mtDNA haplogroup was determined in 162 autism probands, and compared to two sets of population controls. Results show no compelling evidence of an association of any mitochondrial haplogroup in autism. (c) 2007 Wiley-Liss, Inc.
John Wiley & Sons, Inc.
Newcastle University Library, NE2 4HQ, United Kingdom. Tel: 0044 (191) 222 7657
©2015 Newcastle University Library