Paranoid Psychosis and Myoclonus: Flecainide Toxicity in Renal Failure

  1. Lookup NU author(s)
  2. Dr Daniela Lee
  3. Professor Neil Sheerin
Author(s)Ting SM, Lee D, Maclean D, Sheerin NS
Publication type Article
ISSN (print)0008-6312
ISSN (electronic)1421-9751
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Flecainide is a sodium channel blocker used mainly in the treatment of supraventricular arrhythmias. Central nervous system side effects such as dizziness, visual disturbances, headache and nausea are commonly associated with flecainide, but severe central nervous system toxicity is rare. We report the first case of flecainide toxicity in a patient with end-stage renal failure. Cessation of flecainide therapy resulted in a fall in serum flecainide levels, with associated resolution of adverse central nervous system effects. We also review the pharmacokinetics of flecainide in patients with chronic kidney disease. Copyright (c) 2008 S. Karger AG, Basel.
PublisherS. Karger AG
Actions    Link to this publication