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Corticosterone selectively attenuates 8-OH-DPAT-mediated hypothermia in mice

Lookup NU author(s): Professor Hamish McAllister-WilliamsORCiD, Professor Allan Young

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Abstract

The 5-HT1A agonist 8-OH-DPAT produces a hypothermia in mice mediated by somatodendritic 5-HT1A receptors, that is attenuated by antidepressants and corticosterone. The present study investigated if the effect of corticosterone is specific to the serotonergic system or a non-specific effect on thermoregulation. Administration of corticosterone for 3 d had no effect on dopaminergic (apomorphine) or adrenergic (clonidine) hypothermic challenges. However in addition to 8-OH-DPAT, nicotine-induced hypothermia was attenuated by corticosterone. Administration of the selective nicotinic antagonist mecamylamine had no effect on 8-OH-DPAT-induced hypothermia, although nicotine-induced hypothermia was attenuated by the selective 5-HT1A antagonist WAY-100635. This demonstrates a serotonergic-nicotinic interaction in the generation of hypothermia in mice and is consistent with corticosterone selectively attenuating somatodendritic 5-HT1A receptor function.

Publication metadata

Author(s): McAllister-Williams RH, Anderson AJ, Young AH

Publication type: Article

Publication status: Published

Journal: International Journal of Neuropsychopharmacology

Year: 2001

Volume: 4

Issue: 1

Pages: 1-8

ISSN (print): 1461-1457

ISSN (electronic): 1469-5111

Publisher: Cambridge University Press

URL: http://dx.doi.org/10.1017/S1461145701002218

DOI: 10.1017/S1461145701002218

PubMed id: 11343623

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