ePrints

Randomised controlled trial evaluating the effectiveness of behavioural interventions to modify cardiovascular risk factors in men and women with impaired glucose tolerance: Outcomes at 6 months

Lookup NU author(s): Professor Nigel Unwin, Professor Martin White, Professor John Mathers, Emeritus Professor Sir George Sir George Alberti

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.

Abstract

Aims: To evaluate the efficacy of interventions to promote a healthy diet and physical activity in people with impaired glucose tolerance (IGT). Methods: A randomised controlled trial in Newcastle upon Tyne, UK, 1995-98. Participants included 67 adults (38 men; 29 women) aged 24-75 years with IGT. The intervention consisted of regular diet and physical activity counselling based on the stages of change model. Main outcome measures were changes between baseline and 6 months in nutrient intake; physical activity; anthropometric and physiological measurements including serum lipids; glucose tolerance; insulin sensitivity. Results: The difference in change in total fat consumption was significant between intervention and control groups (difference -21.8 (95% confidence interval (CI) -37.8 to -5.8) g/day, P=0.008). A significantly larger proportion of intervention participants reported taking up vigorous activity than controls (difference 30.1, (95% CI 4.3-52.7)%, P=0.021). The change in body mass index was significantly different between groups (difference -0.95 (95% CI -1.5 to -0.4) kg/m2, P=0.001). There was no significant difference in change in mean 2-h plasma glucose between groups (difference -0.19 (95% CI -1.1 to 0.71) mmol/l, NS) or in serum cholesterol (difference 0.02 (95% CI -0.26 to 0.31) mmol/l, NS). The difference in change in fasting serum insulin between groups was significant (difference -3.4 (95% CI -5.8 to -1.1) mU/l, P=0.005). Conclusions: After 6 months of intensive lifestyle intervention in participants with IGT, there were changes in diet and physical activity, some cardiovascular risk factors and insulin sensitivity, but not glucose tolerance. Further follow-up is in progress to investigate whether these changes are sustained or augmented over 2 years. Copyright © 2001 Elsevier Science Ireland Ltd.

Publication metadata

Author(s): Oldroyd JC, Unwin NC, White M, Imrie K, Mathers JC, Alberti KGMM

Publication type: Article

Publication status: Published

Journal: Diabetes Research and Clinical Practice

Year: 2001

Volume: 52

Issue: 1

Pages: 29-43

Print publication date: 01/01/2001

ISSN (print): 0168-8227

ISSN (electronic): 1872-8227

Publisher: Elsevier Ireland Ltd

URL: http://dx.doi.org/10.1016/S0168-8227(00)00244-8

DOI: 10.1016/S0168-8227(00)00244-8

PubMed id: 11182214

Altmetrics

Share