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Detection of disseminated pancreatic cancer cells in lymph nodes by immunohistochemistry: Impact on staging and prognosis

Lookup NU author(s): Jeremy French, Dr Mark Bennett, Richard Charnley

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Abstract

The aim of this study was to identify lymphoid metastases by immunohistochemistry in a group of seven patients undergoing curative resection for N0 staged pancreatic ductal adenocarcinoma to investigate whether this would have consequences regarding staging and prognosis when compared to standard histopathological techniques. All 136 lymph nodes examined were negative using routine histopathological techniques. Immunohistochemistry detected micrometastases in eight lymph nodes. This resulted in upstaging in 3/7 (42.9%) patients from N0 to N1. Median survival of N1 patients (all dead) was 11 months compared to median survival to date of 42.4 months in N0 patients (all alive). Immunohistochemistry enables identification of additional patients with lymphoid metastases tumour at the time of operation, which is related to the observed reduction in median survival. The use of immunohistochemistry in T3 N0 tumours as detected by routine histological methods may be useful in identifying micrometastases to define patients who could benefit from systemic adjuvant therapy.

Publication metadata

Author(s): French JJ, Loverseed A, Bennett MK, Charnley RM

Publication type: Article

Publication status: Published

Journal: Gastrointestinal Oncology

Year: 2002

Volume: 4

Issue: 4

Pages: 223-226

ISSN (print): 1475-956X

ISSN (electronic): 1476-8283

Publisher: Taylor & Francis Ltd.

URL: http://dx.doi.org/10.1080/1475956021000045092

DOI: 10.1080/1475956021000045092

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