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Lookup NU author(s): Dr Hannah Cullup, Professor Anne Dickinson, Dr Jennifer Cavet, Professor Graham Jackson, Dr Peter Middleton
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The interleukin-1 (IL-1) family of cytokines is widely involved in inflammatory processes and diseases with an inflammatory component. Polymorphisms of the IL-1α, IL-1β and IL-1Ra genes have been implicated in a number of autoimmune or inflammatory conditions, with polymorphism of the IL-1Ra gene showing association with severity of graft-versus-host disease (GVHD) after allogeneic bone marrow transplantation (BMT). We compared the clinical outcomes (GVHD and survival) of 115 patients after human leucocyte antigen (HLA)-identical sibling allogeneic BMT with their genotype for two polymorphisms present in the IL-1α gene, which have been implicated in immune-related pathology. Possession of allele 2 of the IL-1α -889 polymorphism and allele 2 of the IL-1α variable number tandem repeat (VNTR) polymorphism in the donor genotype was associated with the occurrence of chronic, but not acute GVHD. A local normal population was also genotyped for these polymorphisms, and subsequent analysis identified conserved haplotypes in this gene region. Haplotypes containing allele 2 at both IL-1α -889 and IL-1α VNTR loci were extremely uncommon, suggesting that both risk alleles would be inherited independently. Both loci could therefore function as independent disease association markers. The polymorphisms of the IL-1α gene could be used to predict chronic GVHD in HLA-matched sibling transplants alongside clinical risk factors.
Author(s): Cullup H, Dickinson AM, Cavet J, Jackson GH, Middleton PG
Publication type: Article
Publication status: Published
Journal: British Journal of Haematology
Year: 2003
Volume: 122
Issue: 5
Pages: 778-787
ISSN (print): 0007-1048
ISSN (electronic): 1365-2141
Publisher: Wiley-Blackwell
URL: http://dx.doi.org/10.1046/j.1365-2141.2003.04510.x
DOI: 10.1046/j.1365-2141.2003.04510.x
PubMed id: 12930389
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