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Lookup NU author(s): Dr Andrew McLaren, Professor John AllenORCiD, Emeritus Professor Alan MurrayORCiD, Dr Clive Ballard, Professor Rose Anne Kenny
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Heart rate variability is used to assess cardiovascular autonomic function. The cholinesterase inhibitor donepezil potentially affects parasympathetic activity. Twenty participants with Alzheimer's disease or dementia with Lewy bodies were treated with donepezil in a pilot study. Power spectral analysis was used to analyse 5 min of beat-to-beat RR interval data in 15 cases. Heart rate variability was significantly reduced following treatment with donepezil; mainly for high frequency (median changed from 581 to 78 ms2; p = 0.001) but also for total power (median changed from 1,563 to 844 ms2; p = 0.047). Donepezil may adversely influence cardiovascular autonomic control. These results indicate the need for larger controlled trials to further investigate the cardiovascular effects of donepezil. Copyright © 2003 S. Karger AG, Basel.
Author(s): McLaren AT, Allen J, Murray A, Ballard CG, Kenny RA
Publication type: Article
Publication status: Published
Journal: Dementia and Geriatric Cognitive Disorders
Year: 2003
Volume: 15
Issue: 4
Pages: 183-188
Print publication date: 01/01/2003
ISSN (print): 1420-8008
ISSN (electronic): 1421-9824
Publisher: S. Karger AG
URL: http://dx.doi.org/10.1159/000068781
DOI: 10.1159/000068781
PubMed id: 12626850
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