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Pathways of post-transcriptional gene regulation in mammalian germ cell development

Lookup NU author(s): Professor David Elliott

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Abstract

Male germ cell development is orchestrated by complex and disparate patterns of gene expression operating in different cell types. The mechanisms of gene expression underlying these have been dissected in the mouse because of its readily available genetics. These analyses have shown that as well as the traditional transcriptional mechanisms, post-transcriptional regulatory pathways of gene expression are essential for mouse spermatogenesis. Proteins essential for germ cell development have been identified which operate at different points throughout the life cycle of RNA from pre-mRNA splicing to translation and RNA decay in the cytoplasm. Recent data suggests that these post-transcriptional pathways respond to environmental cues via signalling pathways. Copyright © 2003 S. Karger AG, Basel.

Publication metadata

Author(s): Elliott D

Publication type: Article

Publication status: Published

Journal: Cytogenetic and Genome Research

Year: 2003

Volume: 103

Issue: 3-4

Pages: 210-216

ISSN (print): 1424-8581

ISSN (electronic): 1424-859X

Publisher: S. Karger AG

URL: http://dx.doi.org/10.1159/000076806

DOI: 10.1159/000076806

PubMed id: 15051941

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