Browse by author
Lookup NU author(s): Dr Marie-Laure Muiras
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Given the presence of continuous endogenous and exogenous sources of stress, mammalian species have evolved complex systems of protection, detoxification and repair, in order to maintain homeostasis during development and until reproductive maturity for the sake of the species. However, since no system is perfect, complete prevention of damage is unlikely to occur. Accumulation of macromolecular damage, including damage to DNA and genomic instability, is considered a driving force for the ageing process and age-related diseases. One of the immediate eukaryotic cellular responses to DNA breakage is the covalent post-translational modification of nuclear proteins with poly(ADP-ribose) from NAD+ as precursor, mostly catalysed by poly(ADP-ribose) polymerase-1 (PARP-1). Poly(ADP-ribosyl)ation is involved in DNA base-excision repair (BER), DNA-damage signalling and regulation of genomic stability. In recent years, many groups have become involved in PARP field, shedding light on new partners for PARP-1, new members of the PARP family and new physiological and pathophysiological properties for the founding member of the poly(ADP-ribose) polymerase super family. The present review focuses on PARP-1 and its role in the maintenance of genome stability and in mammalian longevity. © 2002 Elsevier Science Ireland Ltd. All rights reserved.
Author(s): Muiras M-L
Publication type: Review
Publication status: Published
Journal: Ageing Research Reviews
Year: 2003
Volume: 2
Issue: 2
Pages: 129-148
Print publication date: 01/04/2003
ISSN (print): 1568-1637
ISSN (electronic): 1872-9649
URL: http://dx.doi.org/10.1016/S1568-1637(02)00062-4
DOI: 10.1016/S1568-1637(02)00062-4
PubMed id: 12605957
