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A conserved stress-activated protein kinase regulates a core stress response in the human pathogen Candida albicans

Lookup NU author(s): Professor Brian Morgan, Professor Janet Quinn

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Abstract

Previous work has implicated the Hog1 stress-activated protein kinase (SAPK) in osmotic and oxidative stress responses in the human pathogen Candida albicans. In this study, we have characterized the role of Hog1 in mediating these and other stress responses in C. albicans. We provide evidence that a SAPK-dependent core stress response exists in this pathogen. The Hog1 SAPK is phosphorylated and it accumulates in the nucleus in response to diverse stress conditions. In addition, we have identified Hog1-regulated genes that are induced in response to stress conditions that activate Hog1. These analyses reveal both activator and repressor functions for the Hog1 SAPK. Our results also demonstrate that stress cross-protection, a classical hallmark of the core stress response, occurs in C. albicans between stresses that activate the Hog1 SAPK. Importantly, we find that the core stress response in C. albicans has adapted to the environmental niche of this human pathogen. This niche specificity is reflected by the specific environmental conditions that drive the Hog1-regulated core stress response in C. albicans and by differences in the molecular circuitry that control this response.

Publication metadata

Author(s): Smith DA, Nicholls S, Morgan BA, Brown AJP, Quinn J

Publication type: Article

Publication status: Published

Journal: Molecular Biology of the Cell

Year: 2004

Volume: 15

Issue: 9

Pages: 4179-4190

Date deposited: 20/09/2010

ISSN (print): 1059-1524

ISSN (electronic): 1939-4586

Publisher: American Society for Cell Biology

URL: http://dx.doi.org/10.1091/mbc.E04-03-0181

DOI: 10.1091/mbc.E04-03-0181

PubMed id: 15229284

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