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The case for strategic international alliances to harness nutritional genomics for public and personal health

Lookup NU author(s): Professor John Mathers

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Abstract

Nutrigenomics is the study of how constituents of the diet interact with genes, and their products, to alter phenotype and, conversely, how genes and their products metabolise these constituents into nutrients, antinutrients, and bioactive compounds. Results from molecular and genetic epidemiological studies indicate that dietary unbalance can alter gene-nutrient interactions in ways that increase the risk of developing chronic disease. The interplay of human genetic variation and environmental factors will make identifying causative genes and nutrients a formidable, but not intractable, challenge. We provide specific recommendations for how to best meet this challenge and discuss the need for new methodologies and the use of comprehensive analyses of nutrient-genotype interactions involving large and diverse populations. The objective of the present paper is to stimulate discourse and collaboration among nutrigenomic researchers and stakeholders, a process that will lead to an increase in global health and wellness by reducing health disparities in developed and developing countries. © The Authors 2005.

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Author(s): Kaput J, Ordovas JM, Ferguson L, van Ommen B, Rodriguez RL, Allen L, Ames BN, Dawson K, German B, Krauss R, Malyj W, Archer MC, Barnes S, Bortholomew A, Birk R, van Bladeren P, Bradford KJ, Brown KH, Caetano R, Castle D, Chadwick R, Clarke S, Clement K, Cooney CA, Corella D, da Cruz IBM, Daniel H, Duster T, Ebbesson SOE, Elliott R, Fairweather-Tait S, Felton J, Fenech M, Finley JW, Fogg-Johnson N, Gill-Garrison R, Gibney MJ, Gillies PJ, Gustafsson J-A, Hartman IV JL, He L, Hwang J-K, Jais J-P, Jang Y, Joost H, Junien C, Kanter M, Kibbe WA, Koletzko B, Korf BR, Kornman K, Krempin DW, Langin D, Lauren DR, Lee JH, Leveille GA, Lin S-J, Mathers J, Mayne M, McNabb W, Milner JA, Morgan P, Muller M, Nikolsky Y, van der Ouderaa F, Park T, Pensel N, Perez-Jimenez F, Poutanen K, Roberts M, Saris WHM, Schuster G, Shelling AN, Simopoulos AP, Southon S, Shyong Tai E, Towne B, Trayhurn P, Uauy R, Visek WJ, Warden C, Weiss R, Wiencke J, Winkler J, Wolff GL, Zhao-Wilson X, Zucker J-D

Publication type: Article

Publication status: Published

Journal: British Journal of Nutrition

Year: 2005

Volume: 94

Issue: 5

Pages: 623-632

Print publication date: 01/11/2005

ISSN (print): 0007-1145

ISSN (electronic): 1475-2662

Publisher: Cambridge University

URL: http://dx.doi.org/10.1079/BJN20051585

DOI: 10.1079/BJN20051585

PubMed id: 16277761

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